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含的多分子乳--甘油酸) 纳米纤维:一个体外研究
Fulya Geyik1, Seçil Kaya1, Duygu Elif Yılmaz2
1Faculty of Chemical and Metallurgical Engineering, Department of Bioengineering, Yildiz Technical University, Istanbul 34220, Turkey.
ACS omega
|April 1, 2024
概括
装有 прополис的聚乳-co-glycolic 酸 (PLGA) 纳米纤维显示出显著的抗微生物和伤口愈合特性. 这些生物相容的纳米纤维通过支持细胞迁移和增殖,有效地促进伤口关闭.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 伤口愈合 治愈 伤口愈合
背景情况:
- 纳米纤维具有很高的多孔性,并模仿细胞外基质,使它们适合用于伤口带.
- 聚乳糖糖酸 (PLGA) 纳米纤维是药物输送应用的有希望的支架.
研究的目的:
- 开发和描述用于伤口治疗的加载PLGA纳米纤维.
- 为了评估这些纳米纤维的体外释放,抗氧化,抗微生物和伤口愈合特性.
主要方法:
- 电是用来生产PLGA纳米纤维的.
- 被装入PLGA纳米纤维中,使用掉落方法.
- 扫描电子显微镜 (SEM),富里埃变换红外光谱学 (FTIR),DPPH试验,磁盘扩散方法,MTT试验和伤口划伤试验被用于表征和评估.
主要成果:
- 在PLGA纳米纤维 (PLGA-P37.5,PLGA-P50,PLGA-P100) 中证实了荷载.
- PLGA-P50和PLGA-P100对黄金葡萄球菌和白菌有显著的抗菌活性.
- 含有的纳米纤维与人类纤维细胞具有生物相容性,并通过细胞迁移和增殖促进了伤口的关闭.
结论:
- 含的PLGA纳米纤维是有效的抗菌剂和伤口愈合支架.
- 这些纳米纤维显示出在先进的伤口包裹应用中使用的潜力.
- 这项研究首次评估了加载PLGA纳米纤维的体外伤口关闭特性.
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