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磁力共振成像脑结构和功能网络在帕金森病的变化与REM睡眠行为障碍

Fang Wang¹, Zhigang Zhu¹, Chuanbin Zhou²

¹Department of Neurology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.

Frontiers in aging neuroscience

|April 1, 2024

概括

患有帕金森病 (PD) 和快速眼动睡眠行为障碍 (RBD) 的人表现出大脑结构和连接性的改变. 这些变化,包括灰质体积和功能连接性,与PD患者的RBD严重程度相关.

科学领域:

神经科学是一个神经科学.
神经学神经学
睡眠医学睡眠医学

背景情况:

快速眼动睡眠行为障碍 (RBD) 是帕金森病 (PD) 的常见并发症.
在PD中RBD的潜在机制仍然不完全理解.
在PD中调查与RBD相关的神经解剖学和功能变化至关重要.

研究的目的:

分析RBD (PD-RBD) 的PD患者的灰质体积 (GMV) 和功能连接 (FC) 变化.
探索这些神经成像标记物和RBD严重程度之间的关系.
评估GMV和FC的预测值,以确定PD中的RBD.

主要方法:

基于voxel的形态测量 (VBM) 用于评估65名PD患者和21名健康对照 (HC) 的GMV.
在具有 (PD-RBD) 和没有 (PD-nRBD) RBD 的PD患者之间存在显著的GMV差异的区域进行了功能连接 (FC) 分析.
研究了GMV,FC和RBD严重性得分 (RBDSQ) 之间的相关性,以及ROC曲线分析.

主要成果:

患有PD-RBD的患者在左侧中椎 (MTG) 和双侧椎 (CUN) 中显示出减少的GMV.
在PD-RBD患者中,左MTG和右后中枢 (PoCG) 之间观察到增加的FC,而在双边CUN和右中前额 (MFG) 之间发现了降低的FC.
在MTG中的GMV与RBD严重程度有正相关,而CUN和MTG之间的FC与RBD严重程度有负相关.

结论:

在患有RBD的PD患者中存在显著的GMV和FC变化.
这些神经成像变化与RBD症状的严重程度密切相关.
将临床数据与GMV和FC测量相结合,可以有效地预测PD患者的RBD.

关键词:

帕金森病是帕金森氏症的一种疾病.功能连接性的功能连接性灰色物质体积灰色物质体积快速眼动睡眠行为障碍睡眠行为障碍基于voxel的形态测量方法

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