外体细胞在OSCC和正常细胞之间的通信和治疗中的作用
Xingyue Ma1, Ruisi Yang2, Haiyang Li1
1Department of Oral and Maxillofacial Surgery, School of Stomatology, Hebei Medical University, Key Laboratory of Stomatology and Clinical Research Centre for Oral Diseases, Hebei Province, Shijiazhuang, 050017, China.
Heliyon
|April 1, 2024
概括
外体在口腔状细胞癌 (OSCC) 中起着双重作用,影响细胞相互作用,并作为潜在的药物输送载体. 了解外体机制为OSCC患者提供了新的诊断和治疗策略.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 口腔状细胞癌 (OSCC) 由于患者预后不佳而构成重大挑战,需要新的治疗点.
- 外体细胞,在体液中发现的纳米级囊泡,越来越多地被认为是它们在细胞间通信中的作用以及潜在的生物标志物.
- 外体细胞介导正常和OSCC细胞之间的复杂相互作用,影响癌症的进展和治疗反应.
研究的目的:
- 审查口腔状细胞癌中来自各种细胞来源的外体的分子机制和功能.
- 探索外体分子 (circRNAs, lncRNAs, miRNAs) 在OSCC细胞信号和细胞间通信中的参与.
- 讨论外体在OSCC诊断,预后和治疗应用中的潜力,包括药物输送和克服化疗耐药性.
主要方法:
- 文献综述侧重于外体生物发生,载荷,转移机制和OSCC中的功能作用.
- 对研究OSCC细胞,正常细胞和其他细胞类型 (例如纤维细胞,巨细胞,干细胞) 之间的外体介导信号的分析.
- 检查体液 (血,唾液) 中外体含量的研究及其与OSCC预后和治疗的相关性.
主要成果:
- 外基因组通过转移各种生物活性分子,如circRNAs, lncRNAs和miRNAs来促进OSCC中的细胞间通信.
- 来自OSCC细胞,树皮细胞和免疫细胞的外体调节受体OSCC细胞内的信号通路.
- 外体体与化疗耐药性和作为OSCC治疗的潜在药物递送系统有关.
- 体液中的外体样本对OSCC诊断和预后预测有希望.
结论:
- 外体是OSCC微环境中细胞间通信的关键媒介.
- 外体具有作为口腔状细胞癌的诊断生物标志物和治疗输送载体的巨大潜力.
- 对外体生物学的进一步研究可以指导向疗法的开发,并改善OSCC患者的治疗结果.
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