基体的抗高脂血症作用通过逆胆固醇转移增加了HDL
Bo Li1,2,3, Xian-Fang Chen1, Han-Song Wu1
1Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, Zhejiang, 310014, PR China.
Heliyon
|April 1, 2024
概括
阿特拉提洛德斯大脑根 (AM) 中挥发性和脂溶性成分显著降低了超脂血症. 这些化合物通过提高参与逆胆固醇运输的关键蛋白质来增强HDL-c,改善整体脂质谱和器官功能.
科学领域:
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
- 代谢疾病 代谢疾病
背景情况:
- 在治疗高脂血症方面,Atractylodes macrocephala Rhizome (AM) 有着悠久的使用历史.
- 针对高脂血症的AM的特定活性成分和机制尚不清楚.
研究的目的:
- 为了确定AM中负责其抗高脂血症作用的活性成分.
- 阐明AM对脂质代谢作用的潜在机制.
主要方法:
- 四种不同的AM提取物 (AMW,AMO,AME,AMP) 被测试在SD老鼠中,这些老鼠被养高糖,高脂肪饮食和酒精.
- 网络药理学被用来分析活性成分和预测机制.
- 验证了对高密度脂蛋白胆固醇 (HDL-c) 和逆胆固醇输送 (RCT) 蛋白 (Apo-A1,LCAT,SR-BI) 的影响.
- 评估了和肝功能安全性.
主要成果:
- 富含挥发性和脂溶性成分的AMO提取物显示出最显著的抗高脂血症效应.
- AMO治疗剂量取决于增加的HDL-c水平和上调的Apo-A1,SR-BI和LCAT表达.
- 和肝脏的病理变化得到改善,血清肌素降低.
结论:
- 亚米的挥发性和脂溶性成分是治疗高脂血症的关键活性成分.
- 这些成分通过上调RCT相关蛋白质 (Apo-A1,LCAT,SR-BI) 来增强血清的HDL-c.
- 在高脂血症模型中,AM对脂质概况和器官功能产生有益影响.
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