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Updated: Apr 28, 2026

Isolation of Labile Multi-protein Complexes by in vivo Controlled Cellular Cross-Linking and Immuno-magnetic Affinity Chromatography
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从珍珠矩阵蛋白质中分离出的第一个生物活性 (血管素转化酶抑制剂)

Chaoyi Wu1, Zehui Yin1, Yayu Wang2

  • 1Key Laboratory of Freshwater Aquatic Genetic Resources, Shanghai Ocean University, Ministry ofAgriculture, Shanghai, 201306, China.

Heliyon
|April 1, 2024
PubMed
概括

研究人员发现了一种来自珍珠的新,可以抑制血管酶I转化酶 (ACE). 这种珍珠衍生的显示出作为抗高血压药物的天然来源的潜力.

关键词:
这是一种ACE抑制性.抑制的动态分析.分子对接是分子对接.珍珠矩阵蛋白质是一种珍珠矩阵蛋白质.

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Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
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