综合转录组测序和加权基因共同表达网络分析揭示了乳头甲状腺癌的关键基因
Lingfeng Pan1, Lianbo Zhang1, Jingyao Fu2
1Department of Plastic Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, 130033, China.
Heliyon
|April 1, 2024
概括
这项研究确定了包括AVPR1A和GNA14在内的9个关键基因,这些基因与乳头甲状腺癌 (PTC) 有关. 这些基因提供了潜在的治疗点和对PTC发展和复发的洞察力.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 分子生物学分子生物学
背景情况:
- 乳头甲状腺癌 (PTC) 是最常见的甲状腺癌类型,其特点是复发率高.
- 了解推动PTC的分子机制对于开发有效的治疗方法至关重要.
研究的目的:
- 确定与乳头甲状腺癌 (PTC) 相关的关键基因.
- 获得对PTC发展和复发背后的分子机制的新见解.
主要方法:
- 利用了七个基因表达数据集从基因表达综合数据库用于PTC.
- 应用差异性基因表达分析,蛋白质-蛋白质相互作用网络分析和权重基因共同表达网络分析 (WGCNA).
- 进行了基因组丰富分析 (GSEA),并评估了与免疫透和甲基化水平的关联.
主要成果:
- 确定了九个关键基因 (例如GNA14,AVPR1A,LAMB3,MET) 在PTC中差异表达.
- 发现AVPR1A和GNA14的高表达与更好的无疾病生存率 (DFS) 相相关.
- 关键基因与p53信号传递,亡和上皮细胞-介质细胞过渡等途径有关,并与免疫透和甲基化有关.
结论:
- 已识别的关键基因代表了 papillary thyroid carcinoma (PTC) 的潜在治疗标.
- 这项研究为PTC的分子基础提供了更深入的理解.
- 对这些基因的进一步调查可能会导致改善PTC的诊断和治疗策略.
相关概念视频
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
01:20Synthesis and Regulation of Thyroid Hormones
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...