危险性HIV阳性MSM中的性传播共感染:对最佳预防性治疗的影响
Tzong-Yow Wu1,2, Kuan-Yin Lin1, Li-Hsin Su1
1Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Frontiers in medicine
|April 1, 2024
概括
细菌性传播感染 (STD) 在与男性发生性关系 (MSM) 的HIV阳性男性中很常见. 建议定期查和组合疗法来管理这些普遍的共感染.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 性健康 性的健康
背景情况:
- 同时性传播感染 (STIs) 经常在性活跃的个体中观察到.
- 细菌性传播感染在这个人群中构成严重的健康问题.
研究的目的:
- 确定与男性发生性关系的HIV阳性男性 (MSM) 中细菌性传播感染的流行率和共感染率.
- 评估各种组合治疗方案的潜在益处,以管理并发的细菌性传播疾病.
主要方法:
- 参与者包括艾滋病毒阳性MSM测试的性传播感染,包括*克拉米迪亚形虫病*,*尼塞利亚淋病*,*菌质*种类, *尿质*种类和*阴道菌.
- 多重实时聚合酶链反应测试被用于样本测试.
- 估计共感染率来评估治疗方案的疗效.
主要成果:
- 在535名参与者中,57.9%患有至少一种细菌病原体,32.9%患有并发性感染.
- 最常见的病原体是 *Ureaplasma urealyticum* (36.3%), *Chlamydia trachomatis* (22.8%),和 *Neisseria gonorrhoeae* (19.8%),这些病原体是最常见的病原体.
- 高龄,早期梅毒和更多的性伴侣与增加的性传播疾病风险有关.
结论:
- 细菌性传播疾病在艾滋病毒阳性MSM中很普遍,突出了定期查的必要性.
- 同时感染很常见,这强调了综合管理策略的重要性.
- 需要进一步的研究来调查预防性多克西环林组合治疗对并发性传播疾病的有效性.
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