按性别和药物类别的抗高血压药物坚持趋势:试点研究
Henry Reed Holmes1, Qian Li2, Ke Xu2
1College of Medicine, University of Florida, Gainesville, FL, USA.
概括
使用HPLC-MS评估抗高血压药物坚持的结果显示,心血管疾病患者的不坚持率为29%. 妇女,特别是老年妇女中不坚持更为常见,并且与高血压有关.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
背景情况:
- 抗高血压药物不服药是管理高血压的一个重大挑战.
- 难以准确评估坚持性,影响治疗疗效和患者的治疗结果.
研究的目的:
- 准确评估心血管疾病门诊中心高血压患者的抗高血压药物服药程度.
- 根据使用HPLC-MS的性别和药物类别来识别不遵守的趋势.
主要方法:
- 使用高性能液体染色学-并联质谱法 (HPLC-MS) 来分析血清药物度.
- 将抗高血压药物分为以下类别:β阻塞剂,阿尔多激素对抗剂,利尿剂,ACE抑制剂/ARBs和通道阻塞剂.
- 通过将处方方案与患者血清中检测到的药物水平进行比较来确定坚持.
主要成果:
- 在研究的76名患者中,29%的患者证实不坚持.
- 与男性相比,在女性中观察到更高的抗性高血压 (RHTN) 和非坚持率 (分别为55%与38%和34%与21%).
- 坚持药物治疗的患者血压明显降低 (129/75 mmHg) 比不坚持药物治疗的患者 (145/83 mmHg).
结论:
- 在患有高血压和RHTN的老年女性中,不坚持更为频繁.
- HPLC-MS提供了一种可靠的方法来评估抗高血压药物的坚持.
- 观察到特定于药物类别的不坚持模式,阿尔多激素抗剂和利尿剂在女性和男性中最常见.
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