维斯法丁和牙周炎之间的关联:系统性审查和元分析
Yaoqin Li1, Caihong Xin2, Jing Xie3
1Department of Stomatology, First Affiliated Hospital of Soochow University, Suzhou, China.
PeerJ
|April 1, 2024
概括
与健康个体相比,牙周炎患者的维斯法廷水平显著更高. 这种脂肪细胞因子可以作为诊断和治疗牙周病的宝贵生物标志物.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 牙周病学 牙周病学
背景情况:
- 牙周炎是一种与细菌感染有关的慢性炎症性疾病.
- 维斯法是一种阿迪波金,参与免疫调节.
- 之前的研究指出,牙周炎患者的视法丁含量升高,但相关性尚不清楚.
研究的目的:
- 系统地评估视沙丁水平与牙周炎之间的关联.
- 为了确定visfatin作为牙周病的生物标志物的潜力.
主要方法:
- 通过PubMed,Web of Science,ScienceDirect,EBSCO和威利在线图书馆的研究进行了元分析.
- 使用的关键词是"牙周炎"和"visfatin".
- 计算了具有95%置信区间 (CI) 的标准化平均差异 (SMD).
主要成果:
- 分析包括22篇文章,其中包括456名牙周炎患者和394名对照患者.
- 维斯法廷水平在牙周炎患者中显著更高 (SMD:3.82,95% CI [3.01-4.63]).
- 在治疗牙周炎后,维斯法廷水平显著下降 (SMD: -2.29,95% CI [-3.33至 -1.26]).
结论:
- 这一元分析表明,视法水平与牙周炎之间存在显著的关联.
- 维斯法丁可能是牙周病的潜在诊断和治疗生物标志物.
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