一个真实世界的多中心研究左心房尾闭塞:意大利的多设备体验
Antonio Procopio1, Francesco Radico1, Felice Gragnano2,3
1Heart Department, ASL 02 Abruzzo, Chieti, Italy.
International journal of cardiology. Heart & vasculature
|April 1, 2024
概括
过导管左心房尾阻塞 (LAAO) 是心房患者的一种安全的中风预防方法. 口服抗凝治疗比治疗后的双抗血小板治疗更好的结果.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 医疗器械 医疗器械
背景情况:
- 过导管左心房尾阻塞 (LAAO) 为心房动 (AF) 患者提供了一种替代性中风预防策略,这些患者不适合口服抗凝剂 (OAC).
- 关于LAAO的有效性,安全性和最佳的术后抗血栓策略,存在持续的问题.
研究的目的:
- 评估真实世界的使用,安全性和皮肤穿刺LAAO程序的有效性.
- 评估与各种LAAO后抗血栓治疗方案相关的临床结果.
主要方法:
- 追溯分析了来自6个意大利大批量中心的428名接受皮肤 LAAO 治疗的患者的数据.
- 基于LAAO后的不同抗血栓策略的临床结果的比较.
主要成果:
- 手术并发症的发病率较低 (4.7%为心周溢血/严重出血).
- 出院后使用了不同的抗血小板治疗方案:双抗血小板治疗 (DAPT) (27%),单抗血小板治疗 (SAPT) (26%),OAC (27%).
- 生存分析表明,与DAPT相比,OAC治疗与更好的结果有关.
结论:
- 据证实,LAAO是预防AF中风的安全程序.
- 个性化放出后的抗血栓治疗方案是常见的,平衡了血栓和出血风险.
- 观察到缺血和出血事件的发生率很低.
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