从意大利在线购买的含有选择性雄激素受体调节器的非法产品:对消费者的健康风险
Maria Cristina Gaudiano1, Federica Aureli1, Livia Manna1
1Centro nazionale per il controllo e la valutazione dei farmaci, Istituto Superiore di Sanità, Rome, 00161, Italy.
Sexual medicine
|April 1, 2024
概括
在网上销售的非法选择性雄激素受体调节剂 (SARM) 对健康构成重大风险. 化学分析揭示了未申报的物质和不准确的剂量,突出了这些未经批准的增强性能的药物的危险性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 分析化学 分析化学
- 公共卫生 公共卫生
背景情况:
- 选择性雄激素受体调节剂 (SARM) 是非法销售的合成药物,用于提高表现,特别是在健美运动中.
- 这些物质在欧洲或美国等主要地区没有被批准用于医疗用途.
- 它们在网上日益普及,引发了人们对产品质量和消费者安全的担忧.
研究的目的:
- 调查在线可用的非法SARM产品的质量控制问题.
- 评估与这些产品的广泛使用相关的潜在健康风险.
- 为了记录意大利SARM兴趣和消费的上升趋势.
主要方法:
- 利用基于网络的工具来监控零售网站,搜索趋势和与SARM相关的社交媒体讨论.
- 从意大利的在线零售商那里购买了13种SARM产品.
- 使用质谱和定量核磁共振进行视觉检查和化学分析.
主要成果:
- 误导性产品信息在网站上普遍存在,经常与"仅研究"免责声明相矛盾.
- 意大利对SARM的兴趣明显增加,这得益于在线"科学小说"内容.
- 化学分析显示,只有大约70%的样本含有所述的SARM;23%含有不同的SARM,一个不含任何.
- 在30%的样本中发现未申报的药物物质 (例如,塔莫西芬,塔达拉菲尔),超过60%的样本含有多种活性成分.
- 剂量准确性很差,实际含量从标签声明的30%到90%不等.
结论:
- 作为补充剂销售的在线SARM产品是由于未经批准和未申报的成分而造成的重大健康风险.
- 污染物的存在表明缺乏良好的制造实践,加剧了健康风险.
- 这些发现需要对SARM的使用进行批判性评估,特别是考虑到严重不良事件的报告.
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