免疫检查点抑制剂的临床谱和毒性在过去十年中的演变 - - 全球视角
Paul Gougis1,2,3, Floriane Jochum1,4, Baptiste Abbar2,3,5
1Residual Tumor & Response to Treatment Laboratory, RT2Lab, INSERM, U932 Immunity and Cancer, Institut Curie, Université Paris Cité, Paris 75005, France.
EClinicalMedicine
|April 1, 2024
概括
免疫检查点抑制剂 (ICI) 彻底改变了癌症治疗,但可以导致严重的免疫相关不良事件 (irAE). 这项研究分析了全球的irAE报告,确定了趋势,风险因素和改善患者安全的结果.
科学领域:
- 药物监督 药物监督 药物监督
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 是一种重要的癌症疗法.
- ICI可以引起严重的免疫相关不良事件 (irAE),影响多个器官.
研究的目的:
- 描述irAE报告趋势,临床特征,风险因素和结果.
- 从全球药物监督数据库分析了十多年的irAE数据.
主要方法:
- 从VigiBase (2008-2023) 中提取了irAE数据.
- 分析了报告趋势,临床特征,风险因素和irAE的结果.
- 区分了25种类型的irAE,重点关注ICI疗法和患者人口统计.
主要成果:
- 皮肤反应,肺炎,肠球炎和甲状腺炎是最常见的irAE.
- ICI - 肌毒性显示有很高的重叠;特定的癌症和ICI疗法与某些irAE有关.
- 死亡率最高的是心肌炎,严重肌痛,SCAR,肌炎和肺炎.
结论:
- 本研究提供了关于irAE频谱和特征的最新全球概述.
- 鉴定的风险因素和临床特征可以指导临床实践和未来的ICI安全研究.
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