免疫功能障碍相关的高RDW,APACHE-II和SOFA分数是败血症患者28天死亡的可能原因
Jing Wang1, Lisha He2, Zhiyan Jin1
1Department of Clinical Laboratory, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, Taizhou, Zhejiang Province, People's Republic of China.
Infection and drug resistance
|April 1, 2024
概括
入院时高水平的APACHE II,SOFA和RDW是败血症患者28天死亡率的关键预测因素. 已故患者中的这些高标志物与免疫功能障碍有关,为败血症死亡原因提供了洞察力.
科学领域:
- 关键护理医学 关键护理医学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 败血症仍然是全球死亡的主要原因,需要及早识别高风险患者.
- 了解早期预测因素和死亡原因对于改善败血症患者的治疗结果至关重要.
研究的目的:
- 确定败血症患者28天死亡率的早期预测因素.
- 评估这些标记物的预测价值.
- 调查败血症死亡的潜在原因.
主要方法:
- 对127名败血症患者 (79例存活,48例死亡) 的回顾性分析.
- 对28天死亡率进行风险因素查.
- 接收器运行特征 (ROC) 曲线分析用于预测价值.
- 卡普兰-梅尔生存分析.
- 在已故患者中对细胞因子和淋巴细胞子集的相关性分析.
主要成果:
- 阿帕希II,SOFA和RDW是28天败血症死亡率 (P <0.05) 的重要危险因素.
- 针对APACHE II,SOFA和RDW的单个AUC分别为0.763,0.806和0.723;综合AUC为0.873,3.
- 高APACHE II (≥18.5),SOFA (≥11.5) 和RDW (≥13.8) 与明显更高的28天死亡率 (58.5%,80.5%,59.0%) 相关.
- 在死亡组中,APACHE II与SOFA,IL-2,IL-10;RDW相关,与PLT,TNF-α,CD3+和CD8+淋巴细胞计数相关.
结论:
- 住院时APACHE II,SOFA和RDW分数升高预示着败血症患者28天死亡率的增加.
- 观察到的相关性表明,免疫功能障碍有助于败血症死亡率.
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