在患有COVID-19后疾病的成年人中,一种协生制剂SIM01在6个月内缓解了一些症状
Deepa Gotur1, Eleftherios Mylonakis1
1Houston Methodist Hospital, Houston, Texas, USA (D.G., E.M.).
Annals of internal medicine
|April 1, 2024
概括
一种协生制剂 (SIM01) 改善了后急性COVID-19综合征患者的症状. 这项随机试验表明SIM01是长期COVID恢复的有希望的干预措施.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 后急性COVID-19综合征 (PACS) 在SARS-CoV-2感染后呈现出各种持续症状.
- 肠道失生症与PACS病理生理学有关,这表明可以针对微生物组进行向治疗.
- 对于PACS,目前还没有确定的治疗方法,因此需要新的治疗策略.
研究的目的:
- 评估一种协生制剂 (SIM01) 在患有PACS的患者中的疗效和安全性.
- 评估SIM01对PACS患者症状缓解和生活质量的影响.
主要方法:
- 在香港进行了一项随机,双盲,安慰剂对照试验 (RECOVERY).
- 患有PACS的参与者接受了SIM01 (一种含有Bifidobacterium和Lactobacillus菌株加上果醇糖的共生药物) 或安慰剂,持续了12周.
- 评估了症状严重程度,生活质量和肠道微生物组合.
主要成果:
- 与安慰剂组相比,SIM01组在整体PACS症状得分上显示出显著更大的改善.
- 在SIM01手臂中,疲劳,脑雾和胃肠道问题等特定症状显著减少.
- 在这两组中都没有报告任何重大不良事件,这表明SIM01.01的安全性概况有利.
结论:
- 协生制剂SIM01在缓解与后急性COVID-19综合征相关的症状方面表现出显著的有效性.
- SIM01代表了长期COVID管理的潜在治疗选择,需要在更大的队列中进一步调查.
- 用协生菌向肠道微生物群可能是一个可行的策略,以改善PACS患者的治疗结果.
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