一种葡萄补充饮食通过调节Nrf2和XIAP通路来预防紫外线 (UV) 辐射诱导的白内障
Xiaobin Liu1, Yu Yu1, Luís Aguilera Garcia1
1Pharmaceutical Sciences, College of Pharmacy, University of North Texas Health Science Center, Fort Worth, Texas, USA.
The Journal of nutritional biochemistry
|April 1, 2024
概括
葡萄粉 (GP) 消费保护了小鼠免受紫外线诱导的白内障,通过保存谷氨和防止XIAP抑制. 这表明GP改善了镜片氧化还原稳态,并激活了抗亡途径.
科学领域:
- 眼科医生 眼科 眼科
- 营养科学 营养科学
- 分子生物学分子生物学
背景情况:
- 紫外线 (UV) 辐射是已知的白内障发展的危险因素.
- 氧化应激对紫外线引起的透镜损伤起着重要作用.
- 目前正在探索饮食干预措施的潜在保护作用,以防止眼睛疾病.
研究的目的:
- 在小鼠模型中研究葡萄粉 (GP) 对紫外线诱导的白内障的保护作用.
- 探索GP对透镜的保护作用的潜在分子机制.
主要方法:
- 在3个月内,小鼠被食不同度葡萄粉 (5%,10%,15%) 的饮食.
- 白内障是使用紫外线辐射暴露引起的.
- 分析了谷氨水平,Nrf2激活和XIAP表达.
- 使用Agilent文学搜索 (ALS) 软件预测了GP的分子标.
主要成果:
- 葡萄粉 (GP) 消费剂量取决于抑制紫外线诱导的白内障形成.
- 在镜头中,GP保留了谷氨酸池.
- 在被GP养的小鼠中,紫外线诱导的Nrf2激活被废除,表明改善了氧化还原稳定.
- 总理预防了紫外线诱导的X关联亡抑制剂 (XIAP) 的抑制,这是一个潜在的关键分子标.
结论:
- 葡萄粉 (GP) 在小鼠中显示出显著的保护作用,防止紫外线诱导的白内障发展.
- 医师的保护机制包括增强镜片氧化还原稳定和激活XIAP介导的抗亡路径.
- 饮食葡萄消费可能是预防或减轻紫外线引起的眼睛损伤的可行策略.
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