系统性炎症反应指数与与对比相关的急性损伤之间的关联在接受选择性穿皮冠状动脉干预的患者中
Jun-Han Chen1,2,3, Li-Wei Zhang1,2,3, Wen-Jia Liang1,2,3
1Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.
Renal failure
|April 1, 2024
概括
系统性炎症反应指数 (SIRI) 预测与对比相关的急性损伤 (CA-AKI) 和经过皮肤冠状动脉干预 (PCI) 的患者的死亡率. 高SIRI水平表明CA-AKI的风险增加和PCI后的长期死亡率.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 炎症生物标志物 炎症生物标志物
背景情况:
- 系统性炎症反应指数 (SIRI) 是一种新的生物标志物,反映了中性细胞,单细胞和淋巴细胞的合成.
- 选择性穿皮冠状动脉干预 (PCI) 是一种常见的程序,它与诸如对比相关的急性损伤 (CA-AKI) 等风险有关.
研究的目的:
- 调查SIRI对CA-AKI的预测价值.
- 评估SIRI与接受选择性PCI的患者的长期死亡率之间的关联.
主要方法:
- 在2012年1月至2018年12月期间接受了选择性PCI的5685名患者的回顾性分析.
- 使用中性粒细胞,单细胞和淋巴细胞计数来计算SIRI. 在对比测试后48小时内,根据特定的血清肌素标准定义了CA-AKI.
- 统计分析包括多变量逻辑回归和COX回归,随访时间中位数为2.8年.
主要成果:
- CA-AKI的发生率为6.1%. 一个1.39的SIRI切线显示了CA-AKI的中度预测性能.
- 高SIRI水平 (SIRI>1.39) 独立地与选择性PCI后CA-AKI (OR = 1.642) 和长期死亡率 (HR = 1.448) 的风险增加有关.
- 卡普兰-梅尔曲线证实高SIRI患者的死亡率更高.
结论:
- 升高的SIRI是接受选择性PCI的患者中CA-AKI的独立预测因素.
- 高SIRI水平也与这种患者群体的长期死亡率增加有显著关联.
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