抗生素策略对手术管理的死性肠球炎的结果的影响
Madeline Goldfarb1, Gerald Gollin2
1Texas Tech Health Sciences Center El Paso, Paul L. Foster School of Medicine, El Paso, TX, USA.
Journal of pediatric surgery
|April 1, 2024
概括
术后使用抗生素治疗死角 enterokolitis (NEC) 切除并没有改善结果. 较长的抗生素持续时间和万科米辛与婴儿的真菌感染增加有关.
科学领域:
- 儿科手术 儿科手术
- 新生儿护理 新生儿护理
- 传染性疾病 传染性疾病
背景情况:
- 死性肠球炎 (NEC) 是早产婴儿的一种严重疾病.
- 对NEC的最佳术后抗生素策略尚未明确定义.
研究的目的:
- 评估为NEC进行肠切除的婴儿的术后抗生素实践.
- 为了确定特定的抗生素治疗方案是否与改善的患者结果有关.
主要方法:
- 使用儿科健康信息系统 (PHIS) 数据库 (2016年7月 - 2021年6月) 的回顾性研究.
- 包括130名为急性NEC进行肠切除的婴儿.
- 收集关于抗生素治疗,感染 (皮肤,腹内,真菌,抗生素耐药) 的数据.
主要成果:
- 术后抗生素治疗的平均持续时间为13天;最常见的是万科米辛和 piperacillin/tazobactam.
- 抗生素持续时间>5天并没有降低感染率.
- 没有单一的抗生素显示出更高的疗效;安培素与更多的感染有关.
- 范科米辛的使用与更高的真菌感染发病率有关.
结论:
- 在NEC切除后长时间的抗生素治疗 (>5天) 并没有改善感染结果.
- 没有任何特定的抗生素在预防并发症方面表现出更高的疗效.
- 范科米辛的使用与真菌感染的风险增加有关.
相关概念视频
Inflammatory Bowel Disease V: Surgical Management
145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
145
Peptic Ulcer Disease V: Surgical Management and Nursing Care
302
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
Surgical Interventions for Peptic Ulcer Disease
302
Combined Effects of Drugs: Synergism
3.9K
Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Such synergistic combinations...
3.9K
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
80
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
80
Antibiotic Selection
53.4K
Overview
53.4K


