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肠道微生物群的病原体特异性变化在早产婴儿的尿路感染之前:一个纵向病例对照研究

Luyang Hong¹, Yihuang Huang¹, Junyan Han¹

¹Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China.

|April 1, 2024

概括

在早产婴儿的肠道微生物群和便calprotectin水平的改变可以预测尿路感染 (UTI). 在尿路感染发作之前,特定的细菌增加和calprotectin下降提供了潜在的早期检测生物标志物.

科学领域:

新生儿医学新生儿医学
微生物学微生物学
胃肠病学胃肠病学

背景情况:

尿路感染 (UTI) 在早产婴儿中很常见,由于非特异性症状,具有诊断挑战.
在这种人群中,肠道微生物群对尿路感染病原性的作用尚不清楚.
关于肠道微生物变化及其与早产婴儿尿路感染相关的数据有限.

研究的目的:

为了研究肠道微生物群的变化和便calprotectin水平在早产婴儿和没有尿路感染.
确定住院早产婴儿中尿路感染发展的潜在早期生物标志物.
探索特定肠道微生物特征与尿路感染病原体之间的关联.

主要方法:

一项对151名早产婴儿 (2018-2020年) 的纵向病例控制研究.
每周收集便样本进行微生物分析和calprotectin分析.
倾向性得分对准了围产期因素,包括年龄和抗生素使用.

主要成果:

患有尿路感染的婴儿显示出更高的Enterobacteriaceae和Enterococcaceae的丰度.
观察到病原体特异性种群在尿路感染前显著增加,预测尿路感染.
便中calprotectin水平的下降在尿路感染发作之前发生,特别是在Enterobacteriaceae感染时.

结论:

病原体特异性肠道微生物群的改变在早产婴儿的尿路感染发作之前.
肠道微生物概况和便calprotectin可以作为尿路感染的早期生物标志物.
这些发现提供了关于尿路感染病原学的见解,以及改善早产婴儿早期治疗的潜力.

关键词:

过早出生的婴儿是早产的这是一种calprotectin.微生物组是一个微生物组.尿路感染尿路感染毒性因子是毒性因子.

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