开发和验证宫癌患者的预后名谱:基于SEER的亚洲人口研究
Siyuan Zeng1,2, Ping Yang3, Simin Xiao4
1Department of Obstetrics and Gynecology, Dalian Municipal Central Hospital, Dalian, Liaoning, China.
Scientific reports
|April 1, 2024
概括
这项研究开发了一种名谱仪,用于预测亚洲患者宫癌存活率. 该模型使用年龄,阶段,瘤大小和手术,在预测长期预后方面表现出很好的准确性.
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
- 公共卫生 公共卫生
背景情况:
- 宫癌 (CC) 仍然是亚洲的一个重大健康问题.
- 准确的长期生存预测对于患者管理和资源分配至关重要.
研究的目的:
- 开发和验证一个用于预测亚洲宫癌患者的长期存活概率的命名仪.
- 在亚洲人群中确定宫癌的独立预后因素.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库来收集患者数据.
- 用于特征选择的使用最小绝对收缩和选择运算符 (LASSO) 回归.
- 使用多变量考克斯回归构建了一个预后风险预测模型.
- 使用接收机操作特征 (ROC) 曲线和决策曲线分析 (DCA) 验证了名图.
主要成果:
- 确定年龄,美国联合癌症委员会 (AJCC) 阶段,AJCC T阶段,瘤大小和手术作为独立的风险因素.
- 实现了高的曲线下面积 (AUC) 值:三年 (0.837培训,0.796验证) 和五年 (0.818培训,0.783验证).
- DCA表明了对3年和5年整体存活率 (OS) 的良好临床潜力.
结论:
- 开发的诺米图有效预测亚洲宫癌患者的预后.
- 基于名图的风险分层系统在识别高风险个体方面证明了临床实用性.
- 这种工具可以帮助个性化治疗策略,改善亚洲宫癌患者的治疗结果.
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