基因预测的创伤后应激障碍对自身免疫现象型的影响
Adam X Maihofer1,2,3,4, Andrew Ratanatharathorn5,6, Sian M J Hemmings7,8
1Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. amaihofer@health.ucsd.edu.
Translational psychiatry
|April 1, 2024
概括
创伤后应激障碍 (PTSD) 对自身免疫性甲状腺疾病有因果作用,在PTSD,自身免疫性疾病和炎症生物标志物之间发现了显著的遗传重叠. 这些发现突出了对同时发生的PTSD和自身免疫性疾病的干预途径.
科学领域:
- 遗传学 是一个遗传学.
- 免疫学 免疫学 免疫学
- 精神病学是一个精神病学.
背景情况:
- 观察性研究将创伤后应激障碍 (PTSD) 与自身免疫性疾病风险的增加联系起来.
- 了解共享的生物机制对于治疗PTSD和并发性自身免疫疾病至关重要.
研究的目的:
- 调查PTSD,18种自身免疫疾病和3种免疫/炎症生物标志物之间的共同遗传因素和因果关系.
- 澄清PTSD和自身免疫性疾病之间的因果关系的方向性.
主要方法:
- 使用单变体MiXeR进行遗传架构比较和链接不平衡得分回归用于遗传相关性.
- 进行了双向,两样本的孟德尔随机化 (MR) 和灵敏度分析 (MR-Egger,MR-PRESSO,CAUSE).
- 使用多变量MR来调整潜在的机械路径变量.
主要成果:
- 创伤后应激障碍表现出比自身免疫性疾病更多基因的结构.
- 在PTSD和9种自身免疫性疾病,以及3种炎症生物标志物之间发现了显著的遗传相关性.
- 创伤后应激障碍对自身免疫性甲状腺疾病 (p=0.00009) 和C反应蛋白 (CRP) (p=4.3×10−7) 产生了假定的因果作用.
- 没有自身免疫疾病因果影响PTSD;CRP对PTSD的影响可能被共同的遗传学所混.
结论:
- 在PTSD,自身免疫性疾病和炎症生物标志物之间存在显著的遗传重叠.
- 创伤后应激障碍似乎对自身免疫性甲状腺疾病有因果关系.
- 研究结果表明,针对共享的炎症途径可能有利于管理PTSD和相关的自身免疫性疾病.
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