含有阿司匹林/阿莫西西林的奇托桑微粒和多多巴胺修饰的植入物用于对抗感染和促进骨质生成
Yun Shi1,2, Yongzhen Lai1,2, Yan Guo1,2
1Department of Oral and Maxillofacial Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.
Scientific reports
|April 1, 2024
概括
用阿司匹林和阿莫西西林装载的奇多微球涂层植入物,可以增强骨细胞的生长,减少细菌生物膜的形成. 这种组合有望改善植入物性能和骨质整合.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 传染性疾病 传染性疾病
背景情况:
- (Ti) 植入物在抗菌特性和骨质生成方面存在局限性.
- 酸盐微球为植入物表面的药物输送提供了一个多功能平台.
研究的目的:
- 合成和表征含有阿司匹林,阿莫西西林或两者的奇托桑微球.
- 评估这些修饰的Ti表面对干细胞行为和细菌生物膜形成的影响.
- 评估修改表面的体内抗菌功效.
主要方法:
- 含有阿司匹林,阿莫西西林或阿司匹林+阿莫西西林的奇托桑微球被合成并涂在Ti植入物表面上.
- 分析了表面特征,包括接触角度.
- 评估了大鼠骨髓衍生干细胞 (rBMSC) 的粘附和增殖.
- 黄金葡萄球菌 (S. aureus) 和大肠杆菌 (E. coli) 生物膜的代谢活性在体外测量.
- 在体内对S. aureus的抗菌作用进行了评估.
主要成果:
- 经过修改的Ti表面显示了接触角度的增加.
- 与其他组相比,阿司匹林+阿莫西西林装载的微球显著增强了rBMSC粘附和扩散.
- 在实验室和实验室内观察到阿司匹林 + 氨基素装载的微球,生物膜代谢活性显著降低.
- 在体内测试证实了对S. aureus的抗菌作用.
结论:
- 阿司匹林和阿莫西西林,当结合并加载到酸盐微球上用于Ti植入物涂层时,有效地减轻了细菌活动.
- 这种综合方法促进骨质生成,这表明植入式设备的双重好处.
- 这些发现支持使用阿司匹林和阿莫西西林组合涂层,以改善植入物的结果.
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