化牛奶寡糖的潜在生物功能和未来前景
Thuy Le Lam Nguyen1, Dung Van Nguyen1, Kyung-Sun Heo2
1College of Pharmacy, Chungnam National University, Daejeon, South Korea.
Archives of pharmacal research
|April 1, 2024
概括
在牛奶中发现的Sialyllactoses (SLs) 具有低毒性,对婴儿发育和各种疾病具有健康益处. 本综述涵盖了它们在多个生理系统中的安全性,生产和治疗潜力.
科学领域:
- 生物化学 生物化学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 乳糖 (SLs) 是人乳寡糖 (HMO) 和牛乳寡糖 (BMO) 的关键成分.
- SLs因其在婴儿发育中的关键作用而得到认可,并具有生物活性特性.
- 现有的研究表明,在一系列疾病中,有潜在的健康益处.
研究的目的:
- 综合审查Sialyllactoses (SLs) 的安全性,生物合成和生物效应.
- 探索SLs在各种生理系统和疾病条件中的治疗潜力.
- 巩固研究人员和临床医生对SLs的当前知识.
主要方法:
- 关于Sialyllactoses (SLs) 的现有研究的文献综述.
- 来自动物模型和人体试验的3'-sialyllactose (3'-SL) 和6'-sialyllactose (6'-SL) 的安全数据的分析.
- 综合有关SLs生物合成和生物活动的信息.
主要成果:
- 对3'-SL和6'-SL的安全性评估表明,在动物模型和人类参与者中,毒性较低.
- SLs被强调为婴儿发育至关重要的必需营养素和生物活性成分.
- SLs在胃肠道,免疫,神经和瘤系统以及罕见的遗传疾病和病毒感染中表现出潜在的治疗作用.
结论:
- 乳液 (SLs) 是安全的,并具有显著的健康益处,特别是在婴儿发育方面.
- SLs的多样化的生物活动表明它对各种疾病具有广泛的治疗潜力.
- 对SL的进一步研究可能会为一系列健康状况开启新的治疗策略.
相关概念视频
Protein Glycosylation
6.9K
Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...
Glycosylation occurs in...
6.9K
Oligosaccharide Assembly
2.8K
Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...
Multiple sugar molecules that may or may...
2.8K
Proteoglycans
3.9K
Glycans, a class of complex heterogeneous molecules, can be covalently attached to proteins to form glycosylated proteins that regulate various physiological and pathological processes. Glycosylated proteins or glycoproteins comprise N-linked and O-linked oligosaccharides. O-glycosylation is the most common type of protein glycosylation. Here, glycans attach to the oxygen atom of the hydroxyl groups of Serine or Threonine residues. O-linked glycosylation occurs later in protein processing,...
3.9K
Glucose Transporters
22.7K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.7K
Glycocalyx and its Functions
4.0K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
4.0K
Matrix Proteoglycans and Glycoproteins
3.9K
Proteoglycans are extensively glycosylated proteins, commonly found in the extracellular matrix, interwoven with collagen fibers. Hyaline cartilage, the most common type of cartilage in the body, consists of short and dispersed collagen fibers associated with large amounts of proteoglycans. These proteoglycans have long negative charges that attract cations, which in turn attract water molecules. This influx of ions and water molecules swells up the proteoglycan like a water-soaked gel that can...
3.9K


