奎蒂亚平与哈洛皮多尔在治疗过敏 Delirium:随机对照试验
Tamer Zakhary1, Islam Ahmed2,3, Ibrahim Luttfi4
1Critical Care Medicine Department, Faculty of Medicine, Alexandria University, Alexandria, 21111, Egypt. tamer.zakhary78@alexmed.edu.eg.
Neurocritical care
|April 1, 2024
概括
奎蒂亚平和哈洛佩里多尔在ICU患者的过度活跃狂妄症中表现出类似的有效性. 奎平可以减少ICU停留时间和改善睡眠,但没有提供死亡率的好处.
科学领域:
- 关键护理医学 关键护理医学
- 药理学 药理学是指药理学的学科.
- 精神病学是一个精神病学.
背景情况:
- 过度活动妄想在重症监护室 (ICU) 很常见.
- 非典型抗精神病药物,如奎平,与传统药物,如过敏狂妄症的哈洛佩里多尔相比,其有效性尚未完全被理解.
- 这项研究调查了奎蒂亚平在治疗重症患者过敏 Delirium 的作用.
研究的目的:
- 为了比较奎蒂亚平与哈洛佩里多尔在治疗过敏 Delirium 的疗效.
- 评估这些治疗对妄评分表-修订-98 (DRS-R-98) 评分,ICU停留时间和死亡率的影响.
- 评估二次结果,包括住院死亡率和机械通风的需要.
主要方法:
- 一项随机对照试验,涉及100名被诊断患有过敏 Delirium 的成年患者.
- 患者接受口服叶氨酸 (每天25-50毫克) 或利 (每天1-2毫克).
- 主要结局是应答,定义为DRS-R-98严重性得分减少≥50%,或得分≤12没有复发.
主要成果:
- 总体应答率为92%,可比较的比率在奎蒂亚平和哈洛佩里多尔组之间 (p=0.609).
- 在ICU死亡率,住院死亡率或需要机械通风的群体之间没有发现显著差异.
- 氨酸组显示,平均ICU停留时间的统计显著减少 (p=0.018) 并报告睡眠时间增加 (p=0.001).
结论:
- 奎蒂亚平似乎在治疗危急病患者的过敏 Delirium 症状方面与 haloperidol 一样有效.
- 两种药物都没有证明这种患者群体的死亡率有好处.
- 奎蒂亚平在减少ICU停留时间和改善睡眠质量方面可能具有优势.
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