DNA损伤驱动的炎症性细胞因子:对瘤免疫微环境的重编程和瘤治疗的应用
Meng-Jie Wang1,2, Yu Xia3,4, Qing-Lei Gao5,6
1Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Current medical science
|April 1, 2024
概括
DNA 损伤会影响瘤的发展和免疫微环境. 理解DNA损伤反应和细胞因子对于开发有效的癌症疗法至关重要.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- DNA损伤是瘤发生和瘤进展的一个基本过程.
- 瘤内在的DNA损伤可以触发细胞应激反应,从而塑造瘤的免疫微环境 (TIME).
- 关键的信号通路,如cGAS-STING和ATM/ATR被DNA损伤激活,影响细胞因子分泌.
研究的目的:
- 综合审查DNA损伤反应和瘤内的细胞因子之间的复杂关系.
- 阐明这些细胞因子在瘤免疫微环境中的双重免疫调节作用.
- 总结目前针对DNA损伤相关途径和细胞因子的临床试验,并提供未来的观点.
主要方法:
- 对DNA损伤,细胞因子和瘤免疫微环境研究的文献综述.
- 通过DNA损伤激活的信号通路的分析,包括cGAS-STING和ATM/ATR.
- 来自调查向治疗的临床试验数据的汇编.
主要成果:
- 通过应激反应和细胞因子信号传递,DNA损伤显著影响瘤的免疫微环境.
- 像cGAS-STING和ATM/ATR这样的激活通路调解了具有不同免疫功能的多种细胞因子的分泌.
- 细胞因子在调节抗瘤免疫力方面表现出双重作用,影响治疗策略.
结论:
- 更深入地了解DNA损伤和细胞因子如何重塑TIME对于推进癌症治疗至关重要.
- 准DNA损伤反应通路和相关的细胞因子对新型免疫治疗方法具有前景.
- 新兴技术可能为利用DNA损伤-细胞因子轴在癌症治疗中提供新的途径.
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