与移动性相关的大脑区域将动脉内膜厚度与老年人的特定步行表现联系起来
Xin Zhang1,2, Heyang Lu3, Min Fan4
1School of Public Health, the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
BMC geriatrics
|April 2, 2024
概括
动脉内心介质厚度增加与老年人的步行表现较差有关. 大脑结构,特别是控制运动功能和注意力的区域,调解了这种关联,揭示了行走障碍的潜在机制.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 血管医学 血管医学
背景情况:
- 步态障碍在患有血管疾病的老年人中很普遍.
- 动脉样硬化对走路的具体影响尚不清楚.
- 调查动脉内膜厚度和步态之间的联系对于了解与衰老相关的移动性问题至关重要.
研究的目的:
- 为了检查阴道内心介质厚度 (CIMT) 和特定的步态参数之间的关联.
- 探索大脑结构在调解CIMT和步行表现之间的关系中的作用.
- 阐明患有血管疾病的个体的步态障碍背后的机制.
主要方法:
- 对来自泰州成像研究的707名参与者的横截面分析.
- 使用定时启动和移动,Tinetti测试和定量可穿戴设备分析进行步行评估.
- 大脑区域的体积 (运动,视觉空间,执行,记忆,平衡) 通过MRI量化;进行调解分析.
主要成果:
- Carotid intima-media 厚度与较差的定时起步和起步性能,较慢的步伐和改变的步态对称性相关.
- 步行表现与参与运动控制,视觉空间注意力,执行功能,记忆和平衡的大脑区域有关.
- 特定的大脑区域,包括初级运动皮质,感觉运动区域,额头叶片和脑内皮质,调解了CIMT-gait关联.
结论:
- Carotid intima-media 厚度与老年人的步行性能受损有显著的相关性.
- 特定的功能相关区域的大脑容量调解了CIMT和步行缺陷之间的联系.
- 了解这些神经血管机制对于解决老年人群的步态障碍至关重要.
相关概念视频
01:19The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
01:22Dementia l: Introduction
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...