来自发展中国家的儿科炎性肠病多中心注册表
Pornthep Tanpowpong1, Settapong Jitwongwai2, Teera Kijmassuwan2
1Division of Gastroenterology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
BMC pediatrics
|April 2, 2024
概括
泰国的儿童炎症性肠病 (PIBD) 显示出非常早期发病率很高 (VEO-IBD). 腹和减肥等初始症状预测缓解不良,而女性性别和克罗恩病预测类固醇使用.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠道疾病研究研究
- 临床流行病学临床流行病学
背景情况:
- 全球儿科炎症性肠病 (PIBD) 发病率不断上升.
- 发展中国家缺乏多中心合作研究的PIBD.
- 专注于泰国患有PIBD的儿童.
研究的目的:
- 在泰国儿童中定义PIBD的初始呈现.
- 确定泰国儿童PIBD的短期结果.
- 在泰国建立PIBD的多中心注册表.
主要方法:
- 多中心研究涉及泰国四家教学医院.
- 在19岁以下的儿童中,胃肠内镜和组织病理学证实了PIBD的诊断.
- 数据收集包括人口统计,临床信息和1年的随访治疗.
主要成果:
- 72名儿童被诊断患有PIBD (35名克罗恩病 (CD),36名性结肠炎 (UC)).
- 38%的病例是非常早期发作的IBD (VEO-IBD),平均年龄为7.9岁.
- 与UC相比,CD呈现出更多的炎症症状 (发烧,体重减轻) 和血较少的便.
- 一年后,30.7%的患者没有缓解,43.7%的患者使用了全身性皮质类固醇.
- 腹和体重问题预测无法实现缓解;女性性别和CD预测皮质类固醇使用.
结论:
- 在泰国儿童中发现高比例的VEO-IBD.
- 克罗恩病 (CD) 病例在呈现时显示出更大的炎症负担.
- 最初的腹和体重问题是不良临床缓解的独立预测因素.
- 在一年的随访中,女性性别和CD是皮质类固醇使用的独立预测因素.
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