睡眠呼吸障碍对儿童血清脂质水平的影响:一个病例对照研究
Lei Lei1, XiaoYun Zhang1, Binbin Wang1
1Department of Otorhinolaryngology, Head&Neck Surgery, West China Hospital, West China Medical School, Sichuan University, Sichuan, China.
BMC pediatrics
|April 2, 2024
概括
儿童睡眠呼吸障碍 (SDB) 显著影响血液脂质. 即使是初级打 (PS) 也会提高脂质水平,与此前的观点相反,肥胖会影响甘油三水平.
科学领域:
- 儿科肺病学 儿科肺病学
- 睡眠医学 睡眠医学
- 临床生物化学 临床生物化学
背景情况:
- 儿童睡眠呼吸障碍 (SDB) 包括初级打 (PS) 和阻塞性睡眠呼吸暂停综合征 (OSAS).
- 虽然OSAS与健康问题有关,但PS被认为不那么有害.
- 新出现的证据表明,PS也可能导致心血管,认知和行为问题.
研究的目的:
- 调查血清脂质样本与儿童SDB成分之间的关联.
- 为了比较患有OSAS,PS和健康对照的儿童的脂质水平.
- 探索肥胖在SDB和脂质代谢中的作用.
主要方法:
- 涉及习惯性打或口腔呼吸的儿童 (SDB组) 和匹配的对照组的横截面研究.
- 在SDB组的参与者身上进行了多睡眠学.
- 血清脂质概况 (TC,TG,HDL-C,LDL-C) 使用酶分析测量.
主要成果:
- 与PS和对照组相比,患有OSAS的儿童的TC,TG,LDL-C和LDL/HDL比率显著更高.
- 此外,PS组的脂质水平也高于对照组.
- 血清甘油三酸与最低的氧和负相关,与BMI-z得分正相关;肥胖儿童的TG水平较高.
结论:
- SDB显著影响儿童的血脂概况,即使在没有显著的呼吸暂停或缺氧的情况下,也会影响PS.
- 肥胖与SDB儿童的高甘油三水平特别相关.
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