儿童时代的城市化与情感插曲性记忆相关的条状功能和NTRK2的常见变异有关
Xiao Zhang1,2, Yuyanan Zhang1,2, Hao Yan1,2
1Institute of Mental Health, National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, 51 Huayuanbei Road, Haidian District, Beijing, China.
BMC medicine
|April 2, 2024
概括
儿童时代的城市化增强了对负面刺激的记忆,并改变了大脑的反应,这可能与NTRK2基因有关. 这表明城市环境可能会塑造应激反应的神经通路.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 遗传学 是一个
背景情况:
- 儿童时期的环境 (城市与农村) 可能会影响神经精神疾病的风险.
- 情节性记忆和神经对情绪刺激的反应是潜在的调解因素.
- 遗传因素可能会影响居住选择和环境对记忆的影响.
研究的目的:
- 研究童年城市化对情节性记忆和相关神经机制的影响.
- 探索这些环境-大脑-记忆相互作用的遗传基础.
- 检查城市和农村儿童时期的个体之间的记忆处理和大脑功能的差异.
主要方法:
- 使用中性和厌恶刺激的fMRI情节性记忆范式.
- 在城市和农村儿童群体中编码和检索期间的大脑活动的比较.
- 基因关联分析,包括神经氨酸激酶受体2型 (NTRK2).
主要成果:
- 在城市儿童群体中,对厌恶刺激的检索精度更高.
- 在城市群体中,对厌恶刺激的条形状和海马活动减少.
- 厌恶性刺激的有效条纹编码与NTRK2基因变异之间的关联.
结论:
- 对厌恶性刺激的差异性条形处理可能会将儿童的城市化与对城市压力因素的强烈反应联系起来.
- 神经缩型氨酸激酶受体2型 (NTRK2) 可能在这些神经过程中发挥作用.
- 童年环境显著影响记忆处理和神经反应,有遗传贡献.
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