液体活检技术和肺癌:诊断,监测和评估
1Department of Geriatrics, The First Hospital of China Medical University, Shen Yang, 110000, China.
Journal of experimental & clinical cancer research : CR
|April 2, 2024
概括
液体活检为肺癌检测提供了一种非侵入性的方法. 像循环瘤DNA (ctDNA) 和循环瘤细胞 (CTC) 这样的关键生物标志物显示出早期诊断和监测治疗有效性的前景.
科学领域:
- 在瘤学瘤学.
- 生物标志物发现发现
- 分子诊断学 分子诊断学
背景情况:
- 肺癌是全球主要的癌症,通常在晚期被诊断出来.
- 目前的诊断方法缺乏早期检测的准确性,限制了治疗选择.
- 化疗耐药性和瘤复发是高级肺癌管理中的重大挑战.
研究的目的:
- 审查用于肺癌液体活检的分子生物标志物和试验.
- 突出液体活检在早期诊断和预后评估中的潜力.
- 讨论液体活检在监测治疗反应和复发中的应用.
主要方法:
- 对肺癌液体活检生物标志物的当前文献的综述.
- 分析循环瘤细胞 (CTC),循环瘤DNA (ctDNA),细胞外囊泡 (EV),瘤代谢物,瘤形成的血小板 (TEPs) 和瘤相关抗原 (TAAs).
- 检查用于检测和分析这些生物标志物的测定方法.
主要成果:
- 液体活检为肺癌评估提供非侵入性,持续的采样.
- 包括CTCs,ctDNA,ncRNA,EVs,TAAs和TEPs在内的生物标志物显示出早期诊断的令人鼓舞的结果.
- 液体活检显示出监测治疗反应和检测瘤复发的潜力.
结论:
- 液体活检代表了肺癌诊断和管理的有希望的进步.
- 鉴定的生物标志物为个性化肺癌护理提供了新的策略.
- 进一步的研究和临床验证对于将液体活检完全纳入常规实践至关重要.
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