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Updated: Jun 29, 2025

A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
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A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones

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新型基于isoindolin-1,3-dione的乙酸化衍生物的抗胆酶活性:设计,合成,生物评估,分子动力学研究

Ahmad Nazarian1, Fahime Abedinifar1, Haleh Hamedifar2,3

  • 1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

BMC chemistry
|April 2, 2024
PubMed
概括

研究人员开发了新的基于isoindolin-1,3-dione的乙酸化物,作为乙胆酶 (AChE) 和丁胆酶 (BChE) 的潜在抑制剂. 化合物8a对抗阿尔茨海默病的药物开发表现出强大的抑制和有利的in silico特性.

关键词:
乙烯基胆化酶是一种甲基胆化酶是一种甲基胆化酶.异印林-1,3-二离子分子动力学模拟的模拟.

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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine11:04

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