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亨廷顿病的饮食禁食和时间限制饮食:治疗潜力和潜在机制

Russell G Wells¹, Lee E Neilson^2,3, Andrew W McHill^4,5

¹Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA. wellsru@ohsu.edu.

Translational neurodegeneration

|April 2, 2024

概括

时间限制饮食 (TRE),一种间歇性禁食形式,可能为亨廷顿病 (HD) 提供一种新的治疗策略. 这种生活方式干预显示出清除有毒蛋白质和改善HD进展中涉及的细胞功能的潜力.

科学领域:

神经科学是一个神经科学.
遗传学遗传学是一个
代谢障碍代谢障碍代谢障碍

背景情况:

亨廷顿病 (HD) 是一种致命的神经退行性疾病,由亨廷基因的CAG重复扩张引起,导致突变亨廷 (mHTT) 蛋白质聚合.
目前对HD的治疗方法在很大程度上是症状性的,这凸显了迫切需要疾病修饰疗法和生活方式干预的迫切需要.
时间限制饮食 (TRE) 是一种涉及每日饮食窗口的饮食方法,已成为神经退行性疾病的潜在干预措施.

研究的目的:

探索时间限制饮食 (TRE) 在管理亨廷顿病 (HD) 中的潜在治疗作用.
阐明TRE可能减轻HD病理的潜在生理机制.
评估TRE作为HD患者的生活方式干预措施的可行性.

主要方法:

对TRE及其对神经退行相关细胞通路的影响现有科学文献的审查.
对TRE可能影响HD背景下的mHTT清除,线粒体功能和昼夜节律的拟议机制的分析.
检查了临床前数据,表明TRE在HD模型中的好处.

主要成果:

TRE显示出改善线粒体功能,增强自和减少氧化应激的潜力,这些都是HD病变的关键因素.
TRE可能有助于突变狩猎 (mHTT) 蛋白质聚合物的清除.
这种干预可以恢复条纹性大脑衍生神经营养因子 (BDNF) 水平,并同步昼夜节律,可能缓解HD症状.

结论:

时间限制饮食 (TRE) 是一种有希望的非药物治疗方法,可以减缓亨廷顿病的进展.
了解TRE对mHTT清除,细胞应激和昼夜节律的影响,是开发有效的HD生活方式干预措施的关键.
进一步的临床试验对于验证TRE在患亨廷顿病的人类患者的安全性和有效性至关重要.

关键词:

自自是一种自的过程.循环节律循环节律是指循环节律.饮食禁食是一种饮食禁食.亨廷顿病就是亨廷顿病.断断续续的禁食是一种禁食.生活方式干预措施线粒体生物发生是线粒体生物发生.神经保护是一种神经保护.有时间限制的饮食.

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