输血依赖性thalassemia患者中阴性腺体的比例及其贡献因素
Dian Anindita Lubis1, Imam Subekti, Em Yunir
11. Doctoral Program in Medical Sciences, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia. 2. Division of Endocrinology Metabolic, Department of Internal Medicine, Faculty of Medicine Universitas Sumatera Utara, Medan, Indonesia. dian.anindita@usu.ac.id.
阴性腺缺陷症影响了超过一半的依赖输血的沙拉西米亚患者. 较低的血红蛋白水平预测了这种情况,影响了β-thalassemia患者的性健康和生活质量.
科学领域:
- 内分泌学 在内分泌学.
- 血液学 血液学 血液学
- 生殖健康 生殖健康
背景情况:
- β-thalassemia是一种慢性疾病,导致红细胞形.
- 阴性质下降症是一种并发症,导致性功能障碍和降低生活质量.
- 大约3-10%的印度尼西亚人携带β-thalassemia基因.
研究的目的:
- 为了确定对输血依赖的沙拉西米亚患者中阴性腺体缺血的患病率.
- 为了确定在这个人群中导致低阴性恋的因素.
主要方法:
- 在印度尼西亚对60名男性β-thalassemia患者进行的横截面研究.
- 身体和实验室检查FSH,LH和自由水平.
- 使用了斯皮尔曼等级相关性和ROC曲线分析.
主要成果:
- 在60名患者中,31名患者 (51.7%) 患有阴性腺瘤.
- 输血前的血红蛋白水平与FSH,LH和自由相关.
- ROC分析显示,输血前的血红蛋白是催眠症的可行预测因素.
结论:
- 输血前的血红蛋白计数是输血依赖的血病患者中阴性腺体缺血的潜在预测因子.
- 机制包括组织缺氧和输血导致的铁过载.
- 较低的血红蛋白水平与降低的性激素水平有线相关.
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