类黄补充剂对内皮功能的影响:随机临床试验的系统审查和剂量反应元分析
Farnaz Jalili1, Sajjad Moradi2, Sepide Talebi3,4
1University of Adelaide Faculty of Medicine, Adelide, Australia.
Phytotherapy research : PTR
|April 2, 2024
概括
类黄类补充剂 (CFS) 显著改善内皮功能,通过流介导血管扩张 (FMD) 来衡量. 增加CFS摄入量与更大的口病改善相关,这表明剂量依赖的效果.
科学领域:
- 心血管健康 心血管健康
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 内皮功能障碍是心血管疾病发展的关键因素.
- 类黄酸是具有潜在抗氧化和抗炎性能的植物化合物.
- 关于类黄补充剂 (CFS) 和内皮功能的现有研究需要合成.
研究的目的:
- 对CFS对内皮功能影响的随机临床试验 (RCT) 进行系统审查和元分析.
- 进行剂量反应分析,以量化CFS摄入量与内皮功能之间的关系.
- 评估CFS对流媒体血管扩张 (FMD) 的影响.
主要方法:
- 对RCT进行系统审查和剂量反应元分析.
- 在PubMed,ISI Web of Science和Scopus数据库中进行的搜索截至2023年5月30日.
- 随机效应模型用于组合加权平均差异和95%置信区间 (CI).
主要成果:
- 包括8个带有596名参与者的RCT.
- 与安慰剂相比,CFS显著增加了口病的2.75% (95% CI:1.29,4.20).
- 观察到一种线性剂量-反应关系:每200毫克/天增加的CFS增加了口病的1.09% (95%CI:0.70,1.48).
结论:
- 类黄类补充剂显然可以增强内皮功能.
- 确立了CFS对口病的积极的线性剂量反应效应.
- 为了得出最终的结论,还需要进行更多的大型RCT,持续时间更长,人群多样化.
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