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在使用患者级数据进行历史借款之前,共变量调整的元分析预测 (CA-MAP) 使用患者级数据.

Bradley Hupf1, Yunlong Yang2, Ryan Gryder1

  • 1Takeda Pharmaceuticals, Cambridge, MA, United States.

Journal of biopharmaceutical statistics
|April 2, 2024
PubMed
概括

这项研究引入了一种新的共变量调整的元分析预测 (CA-MAP) 方法,用于药物开发中的历史控制借款. 该方法通过关注共同变量效应相似性,而不仅仅是结果相似性,以克服试验异质性,从而增强借用.

关键词:
同变量调整后的调整.借用历史数据 借用历史数据进行元分析和预测.患者级数据 患者级数据

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