在deferasirox介导的视网膜病变中进行多式成像
Jonathan Caranfa1, William Carrera1, Anna Marmalidou1
1Retina Service, New England Eye Center, Tufts Medical Center, Boston, MA, USA.
European journal of ophthalmology
|April 2, 2024
概括
德费拉西洛克斯可以引起色素视网膜病变,这是一个罕见的副作用. 多式成像显示了长期接受deferasirox治疗的患者的特征性视网膜变化.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 医疗成像医学成像
背景情况:
- 德菲拉西洛克斯是一种口服铁化剂,用于控制铁过载.
- 颜色视网膜病变是一种罕见但严重的deferasirox的不良反应.
- 这项研究介绍了成人中第一个deferasirox视网膜病变的多式成像病例.
研究的目的:
- 在成年患者中呈现deferasirox视网膜病变的病例.
- 为了说明多式成像在诊断和表征deferasirox视网膜病变中的实用性.
- 审查有关deferasirox毒性和视网膜病变的文献.
主要方法:
- 一个63岁的男性患有末期脏病的病例报告. 在deferasirox.
- 使用搜索术语"deferasirox视网膜病变"和"deferasirox毒性"进行文献综述.
- 多式成像包括光学连贯断层扫描,底部自光学,光素血管学和多焦点电网膜学.
主要成果:
- 该患者在经过一年的德费拉西洛克斯治疗后出现了无症状的色素上皮质病变.
- 光学连贯性断层扫描显示了外视网膜和视网膜色素上皮质不连续性.
- 基金斯自光检测显示出低自光,而光素血管图显示出阻断.
- 多焦点电网膜学显示了视网膜振幅的微妙减少.
结论:
- 德费拉西洛克斯视网膜病变可以表现为色素变化和外视网膜异常.
- 多模式成像对于检测和评估deferasirox诱导的视网膜毒性至关重要.
- 对于长期接受deferasirox治疗的患者,建议进行眼科检查.
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