相关实验视频

Updated: Jun 29, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

Published on: December 18, 2016

长期COVID患者的大脑和认知变化与感染恢复的对照受试者相比

Víctor M Serrano Del Pueblo¹, Gemma Serrano-Heras², Carlos M Romero Sánchez³

¹Faculty of Medicine, Albacete, University of Castilla-La Mancha, 02008 Albacete, Spain.

Brain : a journal of neurology

|April 2, 2024

概括

长期的COVID会导致神经问题,许多患者会经历诸如记忆丧失之类的认知缺陷. 脑部成像显示了与这些长期COVID症状相关的白质变化.

科学领域:

神经学神经学
神经科学是一个神经科学.
传染性疾病传染性疾病

背景情况:

长期COVID是一种SARS-CoV-2感染后的持续性疾病,经常涉及神经症状.
负责长期COVID的神经心理障碍的潜在大脑变化尚未得到充分理解.

研究的目的:

详细介绍长期COVID患者的认知特征.
为了绘制长期COVID患者的大脑变化.
调查认知缺陷与大脑变化之间的关联.

主要方法:

招募了83名患有COVID-19后持续的神经症状的患者和22名康复的对照.
进行临床采访,标准化神经心理测试和结构磁共振成像 (MRI).
进行灰质形态测量和全脑结构连接性分析.

主要成果:

与对照组相比,长期COVID患者的全球认知功能显著下降.
48%的长期COVID患者出现了情节性记忆缺陷;27%的患者也表现出整体认知,注意力,工作记忆,处理速度和口语流性受损.
核磁共振扫描显示,患者的左后上时线皮层厚度减少,白质异常普遍存在 (较低的微分异性,较高的辐射扩散性).

结论:

神经长期COVID与明显的大脑变化有关,特别是在白质中.
变化的白质连接性与情节性记忆,整体认知,注意力和口语流性受损相关.
这些发现将特定的大脑变化与长期COVID中的认知功能障碍联系起来.

关键词:

这是一种SARS-Cov-2感染.认知障碍是一种认知障碍.长时间COVID综合征神经成像是一种神经成像.神经心理评估神经心理评估白质的完整性白质的完整性

更多相关视频

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study

Published on: August 18, 2020

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

相关概念视频

Cognitive Development During Adulthood

Cognitive Development During Adulthood

Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...

Long-term Depression

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...

Controls in Experiments

Controls in Experiments

When conducting an experiment, it is crucial to have control to reduce bias and accurately measure the dependent variables. It also marks the results more reliable. Controls are elements in an experiment that have the same characteristics as the treatment groups but are not affected by the independent variable. By sorting these data into control and experimental conditions, the relationship between the dependent and independent variables can be drawn. A randomized experiment always includes a...

Role of Cerebellum and Prefrontal Cortex in Memory

Role of Cerebellum and Prefrontal Cortex in Memory

The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...