跨性别青年在性别确认激素治疗中的骨密度
Micaela K Roy1, Samantha Bothwell2, Megan M Kelsey2
1Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO 80045, USA.
Journal of the Endocrine Society
|April 2, 2024
概括
接受性腺激素释放激素激动剂 (GnRHa) 的跨性别青年可能会对骨矿物质密度 (BMD) 产生影响. 长时间使用GnRHa与较低的BMDZ分数有关,而较高的身体质量指数 (BMI) 与增加的BMD相关.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 青少年医学 青少年医学
- 生殖内分泌学 生殖内分泌学
背景情况:
- 变性青年经常接受激素治疗,包括淋巴激素释放激素激动剂 (GnRHa),其次是性激素.
- 这些治疗对青少年骨矿物质密度 (BMD) 的影响需要进一步研究.
研究的目的:
- 在接受激素治疗的跨性别青年中评估骨矿物质密度 (BMD) Z-分数.
- 在这个人群中检查 GnRHa 使用时间,体重指数 (BMI) 和 BMD 之间的关联.
主要方法:
- 一项涉及56名跨性别年轻人 (年龄在10.4-19.8岁) 的横截面研究.
- 骨矿物质密度 (BMD) 用全身双能X射线吸收计进行评估.
- 统计分析探讨了GnRHa持续时间,BMI和BMDZ分数之间的相关性.
主要成果:
- 总体体质 BMD Z-分数在整个队列中通常略低于平均水平.
- 在GnRHa持续时间和BMDZ分数之间观察到负相关性 (男性规范:r = -0.5,P = .005;女性规范:r = -0.4,P = .029).
- 骨质量Z分数与BMI呈正相关性 (男性规范:r = 0.4,P = .003;女性规范:r = 0.4,P = .004).
- 最低的BMDZ分数是在GnRHa单一治疗的出生时被分配男性 (AMAB) 个体中发现的.
结论:
- 接受GnRHa治疗的跨性别青年可能有略低的BMD Z-分数.
- 较长时间的GnRHa治疗与减少的BMD有关.
- 在接受激素治疗的跨性别青年中,更高的BMI可能与改善的BMD有关.
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