环境重金属暴露和听力损失的基于人口的研究:系统性审查和元分析
Fang Wang1, Frank Böhnke1, Katja Böck1
1Department of Otorhinolaryngology/Head & Neck Surgery Klinikum rechts der Isar der Technischen Universität München München Germany.
Laryngoscope investigative otolaryngology
|April 2, 2024
概括
对和的环境暴露与听力损失有关. 较高的血液金属含量和长期暴露表明更强的相关性,4kHz频率是诊断的关键.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 听力学 听力学是指听力学.
背景情况:
- 关于重金属暴露和听力损失存在不一致的发现.
- 环境因素,包括重金属,与听力损失有关.
- 需要进行系统审查和元分析来澄清这些关系.
研究的目的:
- 调查常见重金属 (,,,,,,,) 暴露与听力损失之间的关联.
- 通过元分析来综合现有证据.
- 为了确定与听力损失相关的特定金属和暴露指标.
主要方法:
- 在主要的科学数据库 (PubMed, Web of Science, Embase, Cochrane, Scopus) 和中国数字图书馆进行系统的文献搜索.
- 选了649篇文章,其中15篇被选中进行元分析.
- 计算整体效应大小以确定关联的强度.
主要成果:
- 在 (Pb) 和 (Cd) 暴露和听力损失之间发现了显著的关联.
- 血液中的金属含量与听力损失严重程度之间存在比例关系.
- 高频听力损失 (4kHz) 显示出比低频更强的相关性 (OR 1.44).
- 在指甲和头发中的 (Ba) 含量与听力损失的相关性比在尿液中更大.
结论:
- 和暴露与人类听力损失有显著的关联.
- 血中重金属度升高和长期暴露指标与听力损失发生率相关.
- 建议使用4kHz频率范围来评估重金属引起的听力损失.
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