枢纽过载和故障是神经大脑网络障碍的最后一个常见途径
1Clinical Neurophysiology and MEG Center, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Network neuroscience (Cambridge, Mass.)
|April 2, 2024
概括
大脑网络枢纽对大脑功能至关重要,容易受到神经系统疾病的影响. 他们的功能障碍导致,中风,多发性硬化症和阿尔茨海默病等疾病,影响患者的治疗结果.
科学领域:
- 神经科学是一个神经科学.
- 临床神经学 临床神经学
- 网络科学 网络科学
背景情况:
- 网络枢纽是高度连接的大脑区域,是信息处理的中心.
- 这些枢纽表现出高的神经活动和新陈代谢,使它们易受病理的影响.
- 了解枢纽功能障碍对于诊断和治疗神经系统疾病至关重要.
研究的目的:
- 审查网络枢纽在各种神经疾病中的作用.
- 识别不同病理的枢纽参与的共同主题.
- 探索枢纽功能障碍的诊断和治疗影响.
主要方法:
- 审查最近关于枢纽参与神经系统疾病的证据.
- 对,中风,多发性硬化和阿尔茨海默病等病理学的常见主题进行分析.
- 讨论神经成像和神经生理技术用于枢纽检测.
主要成果:
- 病理中心有助于发作在发作中蔓延,移除改善了结果.
- 在中风中,中枢的损伤与认知恢复障碍相关.
- 涉及枢纽的网络组织中断与多发性硬化症的认知功能障碍有关.
- 在阿尔茨海默氏症中,过度活跃的枢纽与粉样β和病理相关.
结论:
- 枢纽病理是各种神经疾病的常见因素.
- 早期发现枢纽功能障碍,特别是在阿尔茨海默病中,提供了治疗途径.
- 针对像阿尔茨海默氏症这样的疾病中的网络过敏性,可能会从抗治疗中受益.
更多相关视频
06:37Electroencephalography Network Indices as Biomarkers of Upper Limb Impairment in Chronic Stroke
Published on: July 14, 2023
870
10:50Visualizing Impairment of the Endothelial and Glial Barriers of the Neurovascular Unit during Experimental Autoimmune Encephalomyelitis In Vivo
Published on: March 26, 2019
7.7K
相关概念视频
Disorders of the Nervous Tissue
1.3K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.3K
Neuronal Communication
872
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...
872
Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Neural Regulation
39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
The Blood-brain Barrier
47.3K
Overview
47.3K
Excitatory and Inhibitory Effects of Neurotransmitters
9.9K
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of...
9.9K
