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系统性硬化症患者的听力障碍-我们真正知道什么?
Michał Sieśkiewicz1, Damian Rębacz1, Andrzej Sieśkiewicz1
1Department of Otolaryngology, Medical University of Bialystok, Bialystok, Poland.
Frontiers in medicine
|April 2, 2024
概括
系统性硬化症 (SSc) 患者的听力损失可能比普通人群更常见,但其确切的频率和原因尚不清楚. 需要进一步的研究来了解微血管病在SSc相关听力损失中的作用.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 类风湿病学 类风湿病学
- 系统性自身免疫性疾病
背景情况:
- 系统性硬化症 (SSc) 是一种异质的自身免疫性疾病,进展变化.
- 听力障碍虽然在SSc中不危及生命,但可以显著降低生活质量.
- 在SSc中听力损失现有的医学文献是有限的.
研究的目的:
- 系统地审查和评估当前对系统性硬化症患者听力障碍的理解.
- 综合有关此主题的可用医学出版物的发现.
主要方法:
- 系统的文献审查遵循PRISMA指南.
- 分析了19个相关医学出版物,包括11个原始研究和8个病例报告.
主要成果:
- 与一般人群相比,SSc患者的听力障碍似乎更普遍.
- 在SSc中听力损失的确切频率和潜在机制仍未确定.
- 微血管病变被假设为主要原因,可能会影响内耳的感觉细胞.
- 不完整的听力学诊断可能会导致低估听觉通路损伤.
结论:
- 由于疾病的复杂性和异质性,SSc中听力损失的确切频率和病理机制仍未确定.
- 需要对更大,精心挑选的SSc患者组进行进一步的研究.
- 研究应侧重于微血管病变的动态和全面的听力学评估.
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