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Updated: Jun 29, 2025

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

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MED1 IDR 乙化重组了转录预启动复合体,重新连接了 3D 染色体相互作用,并重新编程了基因表达

Ran Lin, Douglas Barrows, Yan Mo

    bioRxiv : the preprint server for biology
    |April 2, 2024
    PubMed
    概括

    MED1乙化通过协调RNA聚合酶II预启动复合体组合和染色体组织来调节基因表达. 非可乙化MED1通过重组复合体和未折叠的染色体来增强细胞生长和基因表达.

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    Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle09:30

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    Published on: January 26, 2018

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    Chromatin Modification in iPS Cells01:32

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    Chromatin modification alters gene expression; therefore, scientists can add histone-modifying enzymes, histone variants, and chromatin remodeling complexes to somatic cells to aid reprogramming into pluripotent stem (iPS) cells.
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    The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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