针对个性化护理的基因组洞察:激励有风险的个人转向基于证据的健康实践
medRxiv : the preprint server for health sciences
|April 2, 2024
概括
多基因风险评分 (PRS) 可以识别患肺癌和戒烟困难的高风险个体. 这种基因风险分层方法正在不同人群中进行评估,以改善癌症预防和烟草治疗.
科学领域:
- 基因组学就是基因组学.
- 翻译医学是一种翻译医学.
- 公共卫生 公共卫生
背景情况:
- 肺癌和烟草使用是全球主要的健康问题,需要先进的预防策略.
- 多基因风险评分 (PRS) 提供了患者风险分层的潜力,但在肺癌的初级保健中未得到充分利用,特别是在多样化的群体中.
研究的目的:
- 引入GREAT护理范式,利用PRS进行个性化肺癌风险分层和干预.
- 开发和应用跨多元祖先的PRS,以改善初级保健机构的风险评估.
主要方法:
- 使用大规模的,多祖先的全基因组关联研究开发了PRS.
- 在所有祖先的标准化PRS分布.
- 将PRS应用于来自GISC试验,英国生物银行 (UKBB) 和我们所有人研究计划 (AoU) 的561,776名个人.
主要成果:
- 肺癌的显著几率比率 (ORs) 在UKBB (1.85) 和AoU (2.39) 的最高PRS组 (前20%) 中被观察到.
- 在UKBB (1.36) 和AoU (1.32) 发现戒烟困难的OR增加 (前33%) .
结论:
- 基于PRS的模型提供了可靠的,大规模的遗传风险评估,适用于各种人群.
- 该模型在高风险人群中促进健康行为变化的有效性将在两个集群随机临床试验中进行评估.
- 这种方法将基因组数据整合到初级保健中,以提高肺癌预防和戒烟结果.
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