CD47 对于介质细胞原始细胞的扩散和骨折修复是必需的
Kurt Hankenson1, Robert Zondervan1, Christina Capobianco1
1University of Michigan.
Research square
|April 2, 2024
概括
抑制CD47通过减少中细胞原生细胞的增殖来破坏骨愈合,尽管增加了内皮细胞活性. 这导致骨折模型中的骨形成减少.
科学领域:
- 生物医学科学 生物医学科学
- 再生医学是一种再生医学.
- 整形外科 整形外科 整形外科
背景情况:
- CD47是一种细胞表面受体,参与组织修复.
- 它在骨折愈合中的作用仍未得到研究.
- 破坏CD47通常会促进各种组织的损伤修复.
结论:
- CD47抑制会影响非缺血和缺血骨折愈合.
- 这种损伤部分是由于中酶体前代细胞增殖减少.
- 增强的内皮细胞增殖和血管化不能弥补CD47破坏的骨愈合中的MSC功能障碍.
相关概念视频
01:27Fractures: Bone Repair
3.2K
Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the...
3.2K
01:19Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K