母亲周产压力和抑郁症对婴儿DNA甲基化在生命的第一年之间的关联
Sarina Abrishamcar1, Beryl Zhuang, Mara Thomas
1Emory University.
Research square
|April 2, 2024
概括
怀孕和幼儿时期的孕产妇压力和抑郁症与婴儿DNA甲基化 (DNAm) 的变化有关. 这些表观遗传变化可能解释了母亲的心理健康如何影响儿童的发育和健康结果.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发展心理学 发展心理学
- 围产期心理健康问题
背景情况:
- 母亲的压力和抑郁症很普遍,影响胎儿和儿童的发育.
- 母亲心理健康和儿童健康结果之间的生物学联系尚未完全理解.
- 不同的DNA甲基化 (DNAm) 是一个潜在的机制.
研究的目的:
- 调查产前和产后母亲的压力/抑郁和新生儿和12个月大的孩子的DNA甲基化之间的关联.
- 探索母亲逆境对儿童DNA甲基化的累积影响.
主要方法:
- 全表观基因组关联研究 (EWAS) 针对新生儿的带血单核细胞DNA甲基化 (CBMC-DNAm) 和12个月大的外周血液单核细胞DNA甲基化 (PBMC-DNAm) 进行.
- 在怀孕和产后期间,使用感知压力量表 (PSS) 和流行病学研究中心抑郁症问卷 (CESD) 评估了母亲的压力和抑郁症.
- 创建了综合产前和产后逆境评分,以评估累积影响.
主要成果:
- 在产前压力和8个CpG位点 (CBMC-DNAm) 和产前抑郁症和2个CpG位点 (CBMC-DNAm) 之间发现了显著的关联.
- 产后压力与8个CpG位点 (PBMC-DNAm) 相关,产后抑郁症与11个CpG位点 (PBMC-DNAm) 相关.
- 累积逆境评分确定了2个产前和7个产后CpG位点与差异性DNA甲基化相关.
结论:
- 怀孕和幼儿时期的母亲心理健康与后代的差异性DNA甲基化有关.
- DNA甲基化可能会调解母亲的压力/抑郁和儿童健康之间的关系.
- 这些发现突出了监测儿童健康风险的潜在表观遗传生物标志物.
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