一个模块化平台来产生功能性交感神经元内化心脏组合物
Nadja Zeltner1, Hsueh-Fu Wu1, Kenyi Saito-Diaz1
1Universtiy of Georgia.
Research square
|April 2, 2024
概括
研究人员通过与心脏器官共同培养同情神经元来开发人类同情心脏组合物 (hSCAs). 这些心脏模型表现出成熟的结构和功能神经调节,推进疾病建模和药物发现.
科学领域:
- 干细胞生物学 干细胞生物学
- 神经科学是一个神经科学.
- 心血管研究的心血管研究.
背景情况:
- 基于人类多能干细胞 (hPSC) 的器官对研究发育,疾病和药物发现至关重要.
- 大多数现有的有机体缺乏内化,这限制了它们模拟器官功能和组织成熟的神经调节的能力.
- 自主交感神经系统在调节心脏功能方面发挥着至关重要的作用.
结论:
- hSCAs为研究神经心脏相互作用和建模心脏病提供了一个全新的,多功能平台.
- 该模型系统适用于未来的神经心脏毒性查,并可适应其他有机神经元组合.
- 模块化性质允许可互换的神经元和器官类型,扩大研究可能性.
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