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Updated: Jun 29, 2025

Tailoring In Vivo Cytotoxicity Assays to Study Immunodominance in Tumor-specific CD8+ T Cell Responses
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内源性CD28驱动多发性髓瘤中CAR-T细胞的反应

Mackenzie M Lieberman1, Jason H Tong1, Nkechi U Odukwe1

  • 1Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14263, USA.

bioRxiv : the preprint server for biology
|April 2, 2024
PubMed
概括

阻止CD28信号传递在仿制抗原受体 (CAR) T细胞中,阻碍了它们对多发性骨髓瘤 (MM) 的有效性. CD28对CAR T细胞的功能和在骨髓微环境中的持久性至关重要.

关键词:
在CAR T细胞中,CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28 CD28协同刺激是一种共同刺激.代谢 代谢 代谢 代谢多发性骨髓瘤是多发性骨髓瘤的一种.瘤微环境是一个微环境.

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