在流行病学研究中测量相互作用的贝叶斯估计
Shaowei Lin1, Chanchan Hu1, Zhifeng Lin1
1Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, FuZhou, Fujian, China.
PeerJ
|April 2, 2024
概括
这项研究引入了贝叶斯的方法来估计像RERI和AP这样的附加相互作用措施,为频率主义方法提供了有竞争力的替代方案,特别是在流行病学研究中的小样本大小.
科学领域:
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 在流行病学研究中,增剂相互作用至关重要.
- 目前的RERI,AP和S等措施主要使用频率主义方法.
- 对附加性相互作用估计的贝叶斯观点未得到充分探索.
研究的目的:
- 介绍一个贝叶斯框架来估计附加相互作用的措施.
- 为相对过度风险由于相互作用 (RERI),因相互作用 (AP) 的可归因比例和协同作用指数 (S) 开发可信的间隔.
主要方法:
- 采用贝叶斯逻辑回归来计算从后面样本的估计和可信度间隔.
- 通过模拟研究,验证了贝叶斯方法与delta和bootstrap方法的对比.
主要成果:
- 贝叶斯估计在模拟中非常接近真实值.
- 贝叶斯可信区间比三角形方法的置信区间更为平衡和准确,特别是在倾斜的相互作用指标上.
- 贝叶斯方法在小样本大小方面被证明是与引导式方法具有竞争力,并且优于引导式方法.
结论:
- 提出的贝叶斯方法为增材相互作用分析提供了一个强大的替代方案.
- 这种方法有助于流行病学家更有效地识别添加剂规模的相互作用.
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