在患有艾滋病毒相关焦虑症的人群中,大脑功能异常和神经炎症
Yunzhu Shan1, Guangqiang Sun2,3, Jiahao Ji1
1Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Frontiers in psychiatry
|April 2, 2024
概括
患有焦虑障碍的艾滋病毒感染者 (PLWH) 显示大脑功能发生变化和炎症增加. 对PLWH焦虑的早期查和干预对于管理这些神经,免疫和内分泌变化至关重要.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 艾滋病毒感染者 (PLWH) 患焦虑症,免疫功能障碍和荷尔蒙失衡的风险更高.
- 关于艾滋病相关焦虑的神经,免疫和内分泌方面的研究是有限的.
研究的目的:
- 为了比较艾滋病毒相关焦虑障碍 (HIV ANXs) 患者的脑功能,结构,免疫标志物和内分泌因子,与没有精神障碍 (HIV控制) 的艾滋病毒阳性患者进行比较.
主要方法:
- 多模态磁共振成像 (MRI) 用于评估大脑功能和结构.
- 基于种子的功能连接 (FC) 分析来评估区域大脑活动.
- 测量周围血液中的细胞因子,化学因子和内分泌因子.
主要成果:
- 在HIV ANXs中,右下回 (ITG) 的低频波动增加,右上回 (SOG) 的区域均性降低.
- 在HIV ANXs中,ITG,SOG和其他大脑区域之间的功能连接 (FC) 改变.
- 艾滋病毒ANX中炎症前驱化学基因升高,与大脑功能变化相关.
结论:
- 与艾滋病毒相关的焦虑障碍与神经,免疫和内分泌异常有关.
- 建议增加对PLWH焦虑障碍的查和干预.
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