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Updated: May 12, 2026

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诺比利丁减轻了大鼠中甲三甲酸诱导的肝毒性

Filiz Kazak1, Ahmet Uyar2, Pinar Coskun1

  • 1Department of Biochemistry, Faculty of Veterinary Medicine, Hatay Mustafa Kemal University, Hatay, Turkey.

Biotechnic & histochemistry : official publication of the Biological Stain Commission
|April 2, 2024
PubMed
概括

诺比素 (NBL) 可能会保护肝脏和脏免受化学疗法药物甲醇 (MTX) 造成的损伤. 这项研究发现,NBL减少了氧化应激和炎症,减轻了MTX诱导的小鼠肝脏毒性.

关键词:
细胞因子细胞因子肝脏毒性 肝脏毒性甲基特雷克萨酸盐的使用方法没有公告公告氧化应激是一种氧化应激.

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Phase II biotransformation reactions are essential for detoxifying and eliminating xenobiotics, including many pharmaceutical compounds. These reactions typically involve conjugation, the covalent attachment of polar endogenous groups such as glucuronic acid, sulfate, methyl, or acetyl moieties to functional groups introduced during Phase I metabolism. The resulting conjugates are more water-soluble, enabling efficient renal or biliary excretion.The major classes of Phase II enzymes include...