益生菌CMS1对免疫反应和口腔微生物群的影响:一个随机,双盲,安慰剂控制,并行研究
Min Ju Park1, Soo-Yeon Park1, Kyeong Jin Kim2
1Department of Food Science and Biotechnology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea. jiyeonk@seoultech.ac.kr.
Food & function
|April 2, 2024
概括
摄入Weissella cibariaCMS1益生菌通过促进唾液免疫球蛋白A和减少炎症,改善了口腔健康. 它还积极改变了健康个体的口腔微生物组组成.
科学领域:
- 口腔微生物学 口腔微生物学
- 免疫学 免疫学 免疫学
- 益生菌的研究研究.
背景情况:
- 口腔内有复杂的微生物群,对健康和免疫力至关重要.
- 益生菌在疾病预防和治疗方面表现有前途.
- 了解益生菌对口腔环境的具体影响至关重要.
研究的目的:
- 评估 *Weissella cibaria* CMS1 对健康成人的口腔微生物组和免疫功能的影响.
- 为了评估唾液免疫标记物和微生物组成在益生菌摄入后的变化.
主要方法:
- 一个为期12周的随机,双盲,安慰剂对照试验,涉及90名健康受试者.
- 干预涉及每天摄入的 *W. cibaria* CMS1.
- 唾液免疫标志物和口腔微生物群在干预前后进行了分析.
主要成果:
- *W. cibaria* CMS1显著增加了唾液免疫球蛋白A (IgA) 和减少了瘤亡因子-α (TNF-α).
- 口服微生物群分析显示,β多样性发生变化,Firmicutes和Actinobacteria增加,Bacteroidetes和Fusobacteria减少.
- 特别增加了乳杆菌,细菌,链球菌,链球菌和坚果菌.
结论:
- *Weissella cibaria* CMS1积极调节口腔微生物群,并增强口腔免疫功能.
- 益生菌可以通过影响微生物平衡和减少炎症标志物来促进更健康的口腔环境.
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